The "Grito de La Villa de Los Santos" (Nov 10, 1821) was the initial spark and local declaration of freedom from Spain by residents of a small town, acting before the capital it was an uprising by patriots in Villa de Los Santos (Azuero Peninsula) against Spanish rule, considered the first cry or starting point. this represented a local declaration of separation from Spain, inspired by wider independence movements and local grievances. This was significant in that it galvanized other towns and created momentum, leading to the formal independence. 

The First Cry of Independence will be celebrated on Tuesday, November 10, 2026, as it is a fixed annual national holiday with festivities featuring vibrant parades, cultural events, and folkloric presentations in La Villa de Los Santos, but the entire country celebrates where you can expect large parades with students, musical bands, traditional dancers, and official ceremonies. The main celebrations occur in La Villa de Los Santos.